Treatment Planning and Validation

Group leader: PD Dr. Michael Krämer

This work group investigates the interaction of charged particle beams with matter on multiple scales.

Main research topics

  •  Macroscopic dose distribution
    • Adaptive treatment planning
    • "Kill-painting" (e.g. to treat hypoxic tumours)
    • Mathematical optimization algorithms
    • Treatment planning with TRiP98 for combined multi-ion treatments
    • "Space TRiP": adaptation of radiotherapy planning concepts for space radiation protection applications, extension of TRiP98 to higher (FAIR) energies
  • Microscopic Monte Carlo calculations 
    • Low energy electron interactions
    • Radiation chemistry under ultra-high dose rate irradiation
    • Oxygen Effect
    • Nanoparticle radiation enhancement and electron emission from solids
  • Experimental validation of treatment planning
    • Verification of 3D dose distributions
    • Biological verification using gel-based 3D bio-phantoms
    • Biological phantoms with different oxygen concentrations
    • Tests of adaptive treatment plans

Some recent publications

[1] Wälzlein C., Scifoni E., Krämer M., Durante M., Simulations of dose enhancement for heavy atom nanoparticles irradiated by protons, Phys. Med. Biol., 59:1441-1458 (2014); DOI: 10.1088/0031-9155/59/6/1441
[2] Tinganelli W., Durante M., Hirayama R., Krämer M., Maier A., Kraft-Weyrather W.K., Furusawa Y., Friedrich T., Scifoni E., Kill-painting of hypoxic tumours in charged particle therapy; Scientific Reports, 5: 17016 (2015); DOI: doi:10.1038/srep17016
[3] Krämer M., Scifoni E., Schuy C., Rovituso M., Tinganelli W., Maier A., Kaderka R., Kraft-Weyrather W.K., Brons S., Tessonnier T., Parodi K., Durante M., Helium ions for radiotherapy? Physical and biological verifications of a novel treatment modality Med. Phys.,43 (4) :1995 -2004 (2016) PMID: 27036594, DOI: 10.1118/1.4944593
[4] Sokol O., Scifoni E., Tinganelli W., Kraft-Weyrather W., Wiedemann J., Maier A., Boscolo D., Friedrich T., Brons S., Durante M., Krämer M., Oxygen beams for therapy: advanced biological treatment planning and experimental verification, Phys. Med. Biol., 62:7798-7813 (2017)
[5] Krämer M., Scifoni E., Giraudo M., Durante M., GSI-FAIR Scientific Report, p.189 (2017)
[6] Boscolo D., Krämer M., Durante M., Fuss M. C., Scifoni E., TRAX-CHEM: A pre-chemical and chemical stage extension of the particle track structure code TRAX in water targets. Chem. Phys. Lett. 698, 11-18 (2018)
[7] Sokol O., Krämer M., Hild S., Durante M., Scifoni E., Kill painting of hypoxic tumors with multiple ion beams, Phys. Med. Biol., 64:045008 (2019)
[8] Boscolo D., Krämer M., Fuss M. C., Durante M., Scifoni E., Impact of Target Oxygenation on the Chemical Track Evolution of Ion and Electron Radiation. Int. J. Mol. Sci. 21, 424 (2020)
[9] Fuss M.C., Boscolo D., Durante M., Scifoni E., Kraemer M., Systematic quantification of nanoscopic dose enhancement of gold nanoparticles in ion beams, Phys Med Biol. (2020)


  •  TIFPA/INFN (Dr. E. Scifoni) 
  •  DKFZ Heidelberg (Prof. J. Seco)
  •  SUT Thailand (Dr. C. Kobdaj)
  •  MedAustron, Vienna (Dr. P. Fossati)
  • Uni Namur (Prof. S. Lucas)
  •  IFF/CISC, Madrid (Prof. G. García)

Group members

PhD students:
Gianmarco Camazzola