Weapon against tumors, boost for the immune system: Activating X-rays – Signalling cascade in T-cells


This news is based on an press release of the TU Darmstadt

Radiation therapy is a proven approach to destroying tumours. However, it is possible that it might be able to do even more in the future – namely stimulate the immune system at the same time and so fight cancer even more intensively. Researchers led by TU Darmstadt and with participation of GSI Helmholtzzentrum für Schwerionenforschung have found that x-rays trigger a calcium signalling cascade in cells of the immune system. The results have now been published in the “Journal of General Physiology”.

Ionising radiation is successfully used in cancer treatment to kill tumor cells and is an important research topic of the GSI Biophysics Department. Over the past two decades, it has become clear that treatment success can be increased even further if the radiation treatment is combined with measures to stimulate the immune system. In this context, a new study being carried out with researchers from TU Darmstadt and GSI plus researchers from the clinics of the Frankfurt and Homburg universities is attracting attention.

The researchers report in the Journal of General Physiology that the desired stimulating effect on the immune system is triggered directly when T-cells are also irradiated by x-rays. Dominique Tandl, researcher at the Department of Biology at TU Darmstadt, and her co-authors, also including Claudia Fournier and Burkhard Jakob from GSI, demonstrate in the recently published study that clinically relevant doses of x-rays in T lymphocytes trigger a signalling cascade that is typical of the immune reaction that begins with the release of the messenger substance calcium (Ca2+) from internal stores.

Activated by what is known as store operated Ca2+ entry (SOCE), the concentration of Ca2+ in the cells begins to oscillate at a critical frequency, which in turn leads to the displacement (translocation) of a transcription factor from the cytoplasm into the cell nucleus. Once there, this transcription factor initiates gene expression, and the cell begins to make molecules that are important for the immune response, such as cytokines.

Since the irradiation of tumours invariably always affects the blood cells in the target tissue, medicine could utilise the stimulating effect of x-rays on T lymphocytes. The researchers hope that their studies will contribute to improving cancer treatment in the long term, as Professor Gerhard Thiel, head of the Membrane Biophysics Department at the Department of Biology at TU Darmstadt and co-author of the study, says. “It could be possible to enhance the killing effect of ionising radiation on tumour cells and at the same time to stimulate the immune system with the help of this radiation.” (TUDa/BP)

Further information

Press release of the TU Darmstadt

Scientific publication in "Journal of General Physiology“