precision and biological effectiveness by using high-energy protons or carbon ions. There is broad consensus, however, that heavier ions could further enhance tumour control in extremely resistant, hypoxic, and [...] first demonstration of the FLASH effect with high-energy carbon ions was achieved, suggesting that UHDR irradiation with even heavier ions could be both safe and highly effective for resistant tumours. [...] Building on this foundation, the HI-FLASH project will investigate neon-ion (20Ne) FLASH therapy for GBM . Neon ions, with their higher linear energy transfer (LET) and relative biological effectiveness