high linear energy transfer radiation therapy. Part 1: Physics and Radiobiology. Appl Radiat Oncol. 2025; 14 (2):1–8. DOI: 10.37549/ARO-D-25-00003P1 Koffler DM, Ebner DK… Tinganelli W . Eradicating cancer [...] 2013; 54(Suppl 1): i13–i22. Tinganelli W , Ma N-Y, Von Neubeck C, Kraft-Weyrather WK, Durante M. Influence of acute hypoxia and radiation quality on cell survival. J Radiat Res. 2013; 54(Suppl 1): i23–i30. [...] radiation therapy. Part 2: LET painting and other advanced techniques. Appl Radiat Oncol. 2025; 14 (2):1–12. DOI: 10.37549/ARO-D-25-00003P2 2024 Amitrano C, De Francesco S, Durante M, Tinganelli W , Arena