Doctoral student (m/f/d)
GSI Helmholtzzentrum für Schwerionenforschung operates a unique large-scale accelerator for ions. Researchers from around the world use this facility for experiments which help them make fascinating discoveries concerning the building blocks of matter and the evolution of the universe. In addition, they continually develop novel applications in medicine and technology. In the coming years the new international accelerator facility FAIR, one of the largest research projects worldwide, will be built at GSI.
One focus of the Biophysics group is the characterization of the usage of DNA repair pathways for different radiation qualities. The pathway choice is connected to repair fidelity and depends on the applied radiation quality. Besides its importance for our general understanding of radiation action, it is of paramount interest for combining radiotherapy with repair inhibitors.
We are looking for the Department of Biophysics for a
Doctoral student (m/f/d)
Posting ID: 1570-19.157
The project of the thesis comprises experimental work to characterise the utilisation of different DNA double-strand-break repair pathways after irradiation with sparsely (x-rays) or densely ionising radiation (charged particles, mainly protons and carbon ions). In particular, cell microscopy studies of cultured human tumour or normal cell lines expressing fluorescently tagged repair factors after irradiation should be systematically performed and analysed. These data should be complemented by immunocytochemical data. Combination of repair inhibitors with different radiation qualities will give new insights for potential newly adapted radio-therapeutic approaches. Different techniques in molecular biology and biochemistry may complement the radiobiological work in order to measure quantities and interaction of different DNA-repair relevant factors.
What we expect:
- has a keen interest in radiobiological questions
- enjoys doing research in an interdisciplinary field between biology and physics
- is willing to handle cell cultures and independently improve and implement live-cell imaging methods
Experience in these areas is therefore desirable.
- competent supervision
- collaboration in an exciting field of research
- membership of the graduate school HGS-HIRe
We offer a PhD contract of 3 years, starting preferably in January 2020. Salary is equivalent to that for public employees as specified in the collective agreement for public employees (TVöD Bund).
GSI supports the vocational development of women. Therefore, women are especially encouraged to apply for the position.
Handicapped persons will be preferentially considered when equally qualified.
The group leader Dr. Burkhard Jakob will be happy to provide further information (06159/71-2608 or b.jakob(at)gsi.de).
If you find this position exciting and challenging and would like to work in an exceptional, international, strongly technical environment, please send your full application documents including the reference number 1570-19.157 to the following address by January 31, 2020.
GSI Helmholtzzentrum für Schwerionenforschung GmbH
or by email to:bewerbung(at)gsi.de