PhD Student in the "Stem Cell Differentiation and Cytogenetics Group" (all genders)
GSI Helmholtzzentrum für Schwerionenforschung in Darmstadt operates one of the leading particle accelerators for science. In the next few years, the new FAIR (Facility for Antiproton and Ion Research) one of the world's largest research projects, will be built in international cooperation. GSI and FAIR offer the opportunity to work together in this international environment with a team of employees committed to ensure each day to conduct world-class science.
The Biophysics department is an interdisciplinary collaboration of biologists, physicists, chemists, biochemists and technicians. The multidisciplinary research in our group covers a wide range of topics from radiobiology, radiation physics and space research to radiation therapy.
The GSI Biophysics – Department is looking for a
PhD student in the “Stem Cell Differentiation and Cytogenetics Group” (all genders)
Posting ID: 23.46-1550
in part time (65 %) starting from 15th of Juli 2023, or as soon as possible thereafter.
The PhD project is part of the BMBF-funded cooperation ESTRANGE that will be performed in close collaboration with the University of Applied Sciences Aschaffenburg.
Exposure of the brain to ionizing radiation, e.g. during cancer therapy, is associated with severe adverse neurological effects. In ESTRANGE the molecular and intercellular mechanisms of radiation-induced neuropsychological and neurocognitive disorders will be studied using an in vitro brain assembloid model that mimics interactions between various brain regions. Analysis of radiation-induced changes in neuronal networks and alterations in the functional connectivity of brain regions will be the focus of the PhD project.
- Derivation of brain assembloids
- Characterization/quantification of cell-cell interactions and radiation-induced alterations in the cellular composition/interaction of neuronal networks using confocal and light sheet micoroscopic technologies
- Analysis and 3D image processing (of confocal and light sheet images) of neuronal networks/connectomes in brain assembloids using state of the art imaging processing software.
- Master of Science in biology with specification in image processing/optical/microscopy technologies or similar qualification
- Experience in optical technology and 3D image processing preferably in human organ-like in vitro models, software development/programming and data processing is preferred
- Interest in complex cellular in vitro models (brain organoids and assembloids), inter-cellular communication and its characterization/quantification
- Willingness to work in an international team to develop and optimize brain assembloid models based on image analyses and neuronal connectomes
- Knowledge in 3D cell culture techniques is a plus.
We offer working in an exciting, multidisciplinary field of research under competent supervision. You will be part of a large cooperative network and member of the graduate school HGS-Hire.
The contract is limited until February 28, 2026 with a possibility for prolongation. The salary is based on the collective agreement for public employees (Tarifvertrag für den öffentlichen Dienst - TVöD (Bund)). GSI supports the vocational development of women. Therefore, women are especially encouraged to apply for the position. Severely handicapped persons will be preferentially considered when equally qualified.
Questions regarding this position should be sent to the group leader Dr. Insa S. Schröder (i.schroeder(at)gsi.de). Further information about FAIR and GSI is available at www.gsi.de/en and www.fair-center.eu.
If you are interested in this position and would like to work in an exceptional international, strongly technical environment, please send your complete application documents, including your salary expectations and details of your earliest possible starting date, quoting the posting ID 23.46-1550, by 23rd of June 2023 at the latest:
Preferred via the online portal on our job site,
or via email to bewerbung(at)gsi.de
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