9th International Microbeam Workshop

Date/Time: July 15-17, 2010 Location: TUD S3/20 Room: seminar room

P1

MONTE-CARLO DOSIMETRY ON A REALISTIC CELL MONOLAYER GEOMETRY Philippe Barberet, Thomas Brun, Hervé Seznec, Marina Simon, Philippe Moretto and S. Incerti Centre d'Etudes Nucléaires de Bordeaux-Gradignan, Université Bordeaux 1, CNRS/IN2P3, Chemin du Solarium, BP 120, F-33175 Gradignan cedex, France

P2

DETERMINATION OF RADIATION INDUCED SURVIVAL AND PHASE-DELAY USING PREMO™ FUCCI CELL CYCLE SENSOR Miriam A. Barry 1,2, J. Charlie Jeynes1, Michael J. Merchant1, Karen J. Kirkby1, Andrew Nisbet1,2, and Norman F. Kirkby1 1 University of Surrey, UK 2 Royal Surrey County Hospital, UK

P3

KINETICS OF DSBS REPAIR IN HUMAN FIBROBLASTS IRRADIATED WITH G-RAYS AND LOW-ENERGY PROTONS Leonardo Bee1, Sonia Fabris1, Maddalena Mognato1, Cristina Girardi1, Silvia Gerardi2, Roberto Cherubini2 and Lucia Celotti1,2 1 Dipartimento di Biologia, Università di Padova, via U. Bassi 58 B, 35121 Padova, Italy 2 Laboratori Nazionali di Legnaro, INFN, Padova, Italy

P4

HIGH-LET INDUCED DNA DOUBLE STRAND BREAKS UNDERGO EXTENSIVE RESECTION AND ARE REPAIRED BY AN ARTEMIS-DEPENDENT REPAIR PATHWAY Sandro Conrad1, Michael Ensminger1, Gisela Taucher-Scholz2, Markus Löbrich1 1 Technical University of Darmstadt, Department of Biology, Germany 2 GSI Helmholzzentrum für Schwerionenforschung, Department of Biophysik, Darmstadt, Germany

P5

ION INDUCED 53BP1 FOCI DIFFUSE IN MITOSIS AND REASSEMBLE AFTER CELL DIVISION Guanghua Du1, Guido A. Drexler2, Volker Hable3, Christoph Greubel3, Anna A. Friedl2, Reiner Krücken1, Günther Dollinger3 1 Physics Dept. E12, Tech. Uni. München, Germany 2 LRT2, Uni. der Bundeswehr München, Germany 3 Institut für Zellbiologie, Ludwig-Maximilians-Uni. München, Germany

P6

RADIATION INDUCED APOPTOSIS Kharman A. Faraj1, Mazin M. Elias2, Sarah Baatout3 1 Department of Physics, College of science, University of Sulaimanya, Kurdistan Region, Iraq 2 Department of Physics, College of science, University of Al-Nahrain, Baghdad, Iraq 3 Nuclear Research Center (SCK.CEN), Mol, Belgium

P7

OBLIQUE ILLUMINATION IMAGING FOR MICROBEAM TARGETING Andrew Harken, Gerhard Randers-Pehrson, David Brenner Radiological Research Accelerator Facility, Columbia University, USA

P8

PROTEIN KINETICS AFTER ION MICROIRRADIATION Volker Hable1, Tino Brüning1, Christian Burgdorf1, Christoph Greubel1, Guido A. Drexler2, Anna A. Friedl2, Hilmar Strickfaden3, Thomas Cremer3, Günther Dollinger1 1 Angewandte Physik und Messtechnik LRT2, UniBw-München, Germany 2 Strahlenbiologisches Institut, LMU-München, Germany 3 Department Biologie II, LMU-München, Germany

P9

RADIOPROTECTION OF TARGETED AND BYSTANDER CELLS BY METHYLPROAMINE Susanne Burdak-Rothkamm1,2, Andrea Smith3, Pavel Lobachevsky3, Kevin Prise1 and Roger Martin3 1 Queen's University Belfast, UK 2 Present affiliation, Stoke Mandeville Hospital, UK 3 Peter MacCallum Cancer, Australia

P10

TOWARDS THREE-DIMENSIONAL ION BEAM CONFINEMENT INSIDE THE CELL W. Meissl1, T. Ikeda1, T. Kobayashi1, P.H. Schury2, E. Meissl1, K. Ogiwara1, M. Hamagaki1, M. Clever3, K. Maeshima3, T.M. Kojima1, Y. Kanai1, N. Imamoto3, and Y. Yamazaki1 1 Atomic Physics Laboratory, RIKEN, Wako-shi, Saitama, 351-0198 Japan 2 Institute of Physics, University of Tsukuba, Ibaraki, 305-8571 Japan 3 Cellular Dynamics Laboratory, RIKEN, Wako-shi, Saitama, 351-0198 Japan

P11

PRE-LENS ELECTROSTATIC SCANNING FOR THE UNIVERSITY OF SURREY VERTICAL NANOBEAM M.J. Merchant1, J.C.G. Jeynes1, V. Palitsin1, G.W. Grime1, B. Vojnovic2, K.J. Kirkby1 1 Ion Beam Centre, University of Surrey, Guildford, UK 2 Gray Institute for Radiation Oncology and Biology, Oxford, UK

P12

EVALUATION OF THE NUCLEAR-WIDE H2AX PHOSPHORYLATION AFTER DEFINED IRRADIATION WITH HEAVY IONS Barbara Meyer1, Kay-Obbe Voss2, Bruno Merk2, Maren Herrlitz1, Nicole Averbeck1, Marco Durante1,3, Gisela Taucher-Scholz1 1 GSI Helmholtzzentrum für Schwerionenforschung, Biophysik, Darmstadt, Germany 2 GSI Helmholtzzentrum für Schwerionenforschung, Materialforschung, Darmstadt, Germany 3 TU Darmstadt, Institut für Festkörperphysik, Germany

P13

AN IMPROVEMENT IN OPTIMIZING COLLIMATOR SIZES IN GAMMA KNIFE USING ARTIFICIAL NEURAL NETWORK Leyla Moghaddam-Banaem, Saeed Setayeshi, M. G. Maragheh, Mojtaba Shamsaie Faculty of nuclear engineering and physics, AmirKabir Technical University, Tehran

P14

P53BP1 AND MDC1 FOCI FORMATION IN HT-1080 CELLS FOR LOW- AND HIGH-LET MICROBEAM IRRADIATIONS Marita Mosconi1, Ulrich Giesen1, Frank Langner1, Christian Mielke2, Ilaria Dalla Rosa2, and Wilhelm G. Dirks3 1 Physikalisch-Technische Bundesanstalt (PTB), Bundesallee 100, 38116 Braunschweig, Germany 2 Heinrich-Heine-University (HHU), 40225 Düsseldorf, Germany 3 Deutsche Sammlung für Mikroorganismen und Zellkulturen (DSMZ), 38124 Braunschweig, Germany

P15

CARBON-ION MICROBEAM INDUCES BEHAVIORAL CHANGE IN THE SALT CHEMOTAXIS LEARNING OF C. ELEGANS Tetsuya Sakashita1, Michiyo Suzuki1, Yasuko Mutou1, Yuichiro Yokota1, Tomoo Funayama1, Nobuyuki Hamada2, Kana Fukamoto3, Yasuhiko Kobayashi1 1 Microbeam Radiation Biology Group, Life Science and Biotechnology Division, Japan Atomic Energy Agency(JAEA), Japan 2 Radiation Safety Research Center, Nuclear Technology Research Laboratory, Central Research Institute of Electric Power Industry, Japan 3 Laboratory of Silkworm Physiology, Faculty of Textile Science and Technology, Shinshu University, Japan

P16

DIRECT OBSERVATION OF P53 MEDIATED BYSTANDER EFFECT Katsutoshi Sato1, Masaharu Nishikino2, Hodaka Numasaki1, Tetsuya Kawachi2, Teruki Teshima1, Hiroaki Nishimura3 and Nariaki Matsuura4 1 Dept. Medical Phys.& Eng., Osaka University, Japan 2 QuBS, Japan Atomic Energy Agency, Japan 3 ILE, Osaka Univ., Japan 4 Molecular Pathology Lab., Osaka University, Japan

P17

DEPENDENCY OF THE RELATIVE BIOLOGICAL EFFECTIVENESS (RBE) OF 20 MEV PROTONS FROM THE APPLICATION MODE Thomas E. Schmid1, Günther Dollinger2, Christoph Greubel2, Volker Hable2, Olga Zlobinskaya1, Dörte Michalski1, Anna Friedl3, Barbara Röper1, Michael Molls1 1 Department of Radiotherapy and Radiooncology, Technische Universität München, Germany 2 Bundeswehr Universität München, Germany, 3Ludwig-Maximilians-Universität München, Germany 3 Ludwig-Maximilians-Universität München, Germany

P18

THREE DIMENSIONAL ANALYSIS OF DNA DOUBLE-STRAND BREAKS INDUCED IN CELLS AFTER CHARGED PARTICLE MICROBEAM IRRADIATION Hervé Seznec, Philippe Barberet, Sébastien Incerti, Philippe Moretto Centre d'Etudes Nucléaires de Bordeaux Gradignan, Université de Bordeaux1, CNRS/IN2P3, Chemin du Solarium, BP120, 33175 Gradignan, France

P19

A CYTOCHROME-C MEDIATED BYSTANDER EFFECT DEPENDS ON THE P53 STATUS OF IRRADIATED HEPATOMA CELLS Chunlin Shao1, Mingyuan He1, Jianghong Zhang1, Kevin M. Prise2 1 Institute of Radiation Medicine, Fudan University, No. 2094 Xie-Tu Road, Shanghai 200032, China 2 Centre for Cancer Research and Cell Biology, Queen’s University Belfast, Lisburn Road, Belfast BT9 7AB, UK

P20

CARBON IONS WITH ENERGY OF 200 MEV/N INDUCE GENOMIC INSTABILITY IN MICE OFFSPRING A. Shemyakov1, S. Zaichkina1, O. Rozanova1, E. Smirnova1, S. Romanchenko1, V. Balakin2, J. Ružička3 1 Institute of Theoretical and Experimental Biophysics, Moscow region, Pushchino, Russia 2 Physical Technical Center, Lebedev Physical Institute, Moscow reg., Protvino, Russia 3 Slovak Office of Standards, Metrology and Testing, Bratislava, Slovakia

P21

TUMOUR IRRADIATION IN LIVING MICE WITH A PULSED NANOSECOND MICROBEAM C. Siebenwirth1, C. Greubel1, V. Hable1, C. Burgdorf1, G. Du2, L. Tonelli2, O. Zlobinskaya3, T.E. Schmid3, D. Michalski3, T. Wenzl3, S. Schell3, S. Reinhardt4, W. Assmann4, J.J. Wilkens3, B. Röper3, M. Molls3, R. Krücken2, G. Dollinger1 1 Universität der Bundeswehr München, LRT\2, D-85579 Neubiberg, Germany 2 Technische Universität München, Physik Department E12, D-85748 Garching, Germany 3 Klinik für Strahlentherapie und Radiologische Onkologie, Technische Universität München, Klinikum rechts der Isar, D-81675 München, Germany 4 Ludwig-Maximilians-Universität München, Fakultät für Physik, D-85748 Garching, Germany

P22

MICROBREAM X-RAY IRRADIATION SYSTEM AT CRIEPI AND ITS USE IN STUDYING BYSTANDER RESPONSE Masanori Tomita1, Munetoshi Maeda1, Katsumi Kobayashi2 1 Radiation Safety Research Center, Central Research Institute of Electric Power Industry, Japan 2 Photon Factory, High Energy Accelerator Research Organization (KEK), Japan

P23

COMPARISON OF AUTOMATIC AND MANUAL COUNTING OF THE PROTEIN FOCI IN THE TRAJECTORIES OF CARBON IONS Laura Tonelli1, Guanghua Du1, Günther Dollinger2, Reiner Krücken1 1 Physik Dept. E12, Tech. Uni. München, Germany 2 LRT2, Universität der Bundeswehr München, Germany

P24

BYSTANDER EFFECTS IN C ELEGANS INDUCED BY MICROBEAM IRRADIATION Jie Sun, Xiaoyin Guo, Jun Wang, Lianyun Chen, Lijun Wu Key Laboratory of Ion Beam Bioengineering, Institute of Plasma Physics, Chinese Academy of Sciences, China

P25

EVIDENCE FOR RADIATION-INDUCED GENOMIC INSTABILITY IN PLANT CELLS Yuichiro Yokota1, Tomoo Funayama1, Yoshihiro Hase1, Nobuyuki Hamada2, Yasuhiko Kobayashi1 , Atsushi Tanaka1 , Issay Narumi1 1 Life Science and Biotechnology Division, Quantum Beam Science Directorate, Japan Atomic Energy Agency, Japan 2 Radiation Safety Research Center, Nuclear Technology Research Laboratory, Central Research Institute of Electric Power Industry, Japan

P26

CHANGES IN CELL CYCLE AFTER IRRADIATION WITH 20 MEV PROTONS IN TWO DIFFERENT APPLICATION MODES Olga Zlobinskaya1, Thomas E. Schmid1, Günther Dollinger2, Christoph Greubel2, Volker Hable2, Dörte Michalski1, Barbara Röper1, Michael Molls1 1 Department of Radiotherapy and Radiooncology, Technische Universität München, Germany 2 Bundeswehr Universität München, Germany

P27

MICROBEAM TECHNOLOGY DISSEMINATION IN THE 21ST CENTURY Carl D. Elliston, David J. Brenner, Steven Marino, Charles R. Geard, Alan Bigelow, and Gerhard Randers-Pehrson Center for Radiological Research, Columbia University Medical Center, New York, USA

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Letzte Aktualisierung: 14. Juli 2010